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Faculty of Health Sciences
School of Medicine
Department of Immunology
Selected Highlights from Research Findings
Several important milestones originated from the Department's tuberculosis and inflammation research programmes in 2003. These include: the generation of potassium transport knockout mutants of Mycrobacterium tuberculosis for drug/ vaccine research in tuberculosis; the observation that transition metals that are present in the workplace and environment catalyse the reactivity of toxic/ caranogenic reactive oxidants produced by the cells of the human immune system – this presents a novel mechanism of environmental and occupational inflammatory diseases of the airways and cardiovascular system; and itraconazole, a widely-used anti-mycotic, is a potent antagonist of the stone-operated influx of calcium into immune and inflammatory cells, which represent a novel pharmacological strategy for the control of harmful inflammatory responses.
Contact person: Prof R Anderson.
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