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Pharmacological regulation of phagocyte activation in chronic inflammatory disorders
To identify novel molecular targets which modulate the harmful pro-inflammatory activities of human leucocytes and to develop pharmacological strategies based on these targets. The results of this project are applicable to the treatment of chronic inflammatory disorders such as bronchial asthma and rheumatoid arthritis Research Output
Research articles in refereed specialist journals
Feldman C, Anderson R, Theron AJ, Steel HC, Van Rensburg (Medlen) CEJ, Cole PJ, Wilson R: 2001. Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. European Respiratory Journal, 18, pp 122-129. Tintinger GR, Theron AJ, Anderson R, Ker JA: 2001. The anti-inflammatory interactions of epinephrine with human neutrophils in vitro are achieved by cyclic AMP-mediated accelerated resequestration of cytosolic calcium. Biochemical Pharmacology, 61, pp 1319-1328. Tintinger GR, Theron AJ, Steel HC, Anderson R: 2001. Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease. Clinical and Experimental Immunology, 123, pp 254-263. Van Rensburg (Medlen) CEJ, Malfeld SCK, Dekker J: 2001. Topical application of oxifulvic acid suppresses the cutaneous immune response in mice. Drug Development Research, 53, pp 29-32. |