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Faculty of Health Sciences
School of Medicine
Immunology
   
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Investigation of the interactions of pneumolysin with human neutrophils in vitro

This project has been designed to elucidate the involvement of the Streptococcus pneumoniae-derived toxin pneumolysin in the intense inflammatory reactions which are a feature of pneumococcal pneumonia and to devise strategies by which these pro-inflammatory actions of pneumolysin can be neutralised

Research Output
Research articles in refereed specialist journals

Cockeran R, Steel HC, Mitchell TJ, Feldman C, Anderson R: 2001. Pneumolysin potentiates production of prostaglandin E2 and leukotriene B4 by human neutrophils. Infection and Immunity, 69(5) / May, pp 3494-3496.

Cockeran R, Theron AJ, Steel HC, Matlola NM, Mitchell TJ, Feldman C, Anderson R: 2001. Proinflammatory interactions of pneumolysin with human neutrophils. Journal of Infectious Diseases, 183 / Feb, pp 604-611.