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Faculty of Natural and Agricultural Sciences
School of Biological Sciences
Biochemistry
  
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The biochemistry, immunology and molecular biology of parasites and bacteria of medical-veterinary significance in Southern Africa

Proteins of the malaria parasite are investigated as targets for the prevention/ treatment of infections by new therapeutic approaches. Research is done on the role of non-protein components of the membranes of tuberculosis and coryza bacteria in the protection against and diagnosis of the pathogens. Molecular biology approaches are used to establish the character and effects of components of tissue and salivary fluids of ticks on their hosts

Research Output
Research articles in refereed specialist journals

Goodrum MA, Siko DGR, Niehues T, Eichelbauer D, Verschoor JA: 2001. Mycolic acids from Mycobacterium tuberculosis: Purification by countercurrent distribution and T-cell stimulation. Microbios, 106, pp 55-67.

Joubert F, Neitz AWH, Louw AI: 2001. Structure-based inhibitor screening: A family of sulfonated dye inhibitors for malaria parasite triosephosphate isomerase. Proteins: Structure, Function, and Genetics, 45, pp 136-143.

Mans BJ, Venter JD, Vrey P, Louw AI, Neitz AWH: 2001. Identification of putative proteins involved in granule biogenesis of tick salivary glands. Electrophoresis, 22, pp 1739-1746.

Maritz C, Louw AI, Gothe R, Neitz AWH: 2001. Neuropathogenic properties of Argas (persicargas) walkerae larval homogenates. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiol, 128(2), pp 233-239.

Prozesky EA, Meyer JJM, Louw AI: 2001. In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected South African plants. Journal of Ethnopharmacology, 76, pp 239-245.