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Faculty of Health Sciences
School of Medicine
Department of Pharmacology
Selected Highlights from Research Findings
The Department of Pharmacology compared the effects of oral administration of a leonardite derived humate with prednisilone on contact hypersensitivity induced in rats. Rats were sensitized with dinitrofluorobenzene (DNFB) and challenged 6 days later with a topical application thereof to the dorsal surface of the right ear. The inflamed ears were measured daily. The leonardite humate compared favourably with prednisilone in suppressing contact hypersensitivity. The safety of this product was also tested on rats and it was found that it had no toxic effects at dosages up to 1g/Kg body weight over a period of 30 days. The effective anti-inflammatory activity of leonardite humate, together with its lack of toxicity makes this compound an ideal candidate to test in clinical trials of inflammation.
Contact person: Prof CEJ Van Rensburg-Medlen.
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