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Faculty of Health Sciences
School of Medicine
Department of Medical Virology
Selected Highlights from Research Findings
Class 1 integrons occur randomly in nosocomial bacterial isolates and have been associated with resistance against antimicrobials and disinfectants. Research conducted in the Department of Medical Microbiology has indicated that the genetic structure is relatively stable for genetic mutations during short term selective antimicrobial pressure in vitro. From this study it can be concluded that short courses of antibiotics at the required dosages do not contribute to genetic mutations and increasing antimicrobial resistance.
Klas 1 integrons kom vryelik voor in nosokomiale bakteriele isolate en word geassosieer met weerstand teen antimikrobiale en ontsmettingsmiddels. Navorsing in die Departement Geneeskundige Mikrobiologie toon dat hierdie genetiese strukture betreklik stabiel is ten opsigte van genetiese mutasies tydens korttermyn selektiewe antimikrobiale druk in vitro. Die gevolgtrekking van hierdie werk impliseer dus dat kort kursusse antibiotika, teen voldoende doserings, nie aanleiding gee tot genetiese mutasie en toenemende antimikrobiale weerstand nie.
Contact person: Dr MM Ehlers.
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